Digg It - Business

With corona treating, the goal is to increase the materials surface energy to provide wet ability and adhesion. But, treating a plastic film or substrate can be ineffective when the system is not properl

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

y run and maintained. So you must be aware of how to effectively process the various materials or substrates.

Over or under corona treating can transfer too much energy to a plastic substrate which is w

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

here a lot of problems could occur when printing or converting of plastic material. When attempting to obtain satisfactory printing results on under treated material can result in the use of excessive am

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ounts of ink in an effort to try to make up for the low treatment levels. Over treatment can result in damage to the material itself as well as problems with the plastic film or plastic tubing blocking t

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ogether.

Poor ink adhesion, or low dyne levels can occur. How you can establish a good starting point is with the power level. You begin by working your way u until the anticipated dyne level is achieve

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

d this is done through quality assurance checks of the plastic film. Once the power level is established for the given product at the given speed, note the power level so when your next time you run the

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

same material and machine speeds you will have a set standard and can be assured of desired repeatability.

Plastic film converters can achieve proper treat levels through trial and error. Testing protoc

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ls which include adhesion and bond strength measurements at a variety of power levels should be used to determine the acceptable power level for each substrate or material type, material thickness, and e

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ven material suppliers are all variables which can impact the appropriate power level. Once determined, the appropriate power settings should become a permanent part of the job specification.

Accurate w

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

eb tension effects plastic film treatment which if not controlled properly can cause variances in surface treatment. With too much tension the material can wrinkle or snap whereas a lack of tension creat

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

es air gaps between the material and roll. In both cases the material can become unevenly treated. Also can cause another problem called backside treating.

Materials that do not come in close contact wi

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

th the treater roll under the electrode or back up roller can affect the treatment process. Wrinkles in the material or air getting trapped under the material can result in some treatment of the back sid

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e of the material which will result in reduce treatment level in respect to the top part of the material and may cause the material to stick together or block.

There are ways to ensure proper tension is

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

to consider nip rolls as they will eliminate concerns with developing an air pocket between the back up roll and the plastic film. Also in some cases you may want to have a spreader roll or a crowned ro

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

l to help eliminate any wrinkles especially at higher production speeds.

Maintaining the surface treatment equipment is very important to help reduce long production downtimes. Proper cleaning of the eq

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

uipment will reduce this downtime.

Many materials tend to clog up or coat the electrodes or air take away systems for example materials like slip and other additives during the corona treatment process.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

The material acts like dirt and can be deposited on the rollers or electrodes. The dirt build up can contribute to producing backside treating causes high and low spots on the treater roll which allows

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

for air gaps that changes the variance in the levels of treatment.

This is one thing plastic converters can do is maintain the treater equipment. Inspect the rollers and electrodes when you have a web

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

break, inspect the rollers for un-wanted particles. Assure your exhaust and cooling air is working properly especially during high humidity months. With a little care and designed scheduled maintenance y

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

our equipment will last a long time but best of all product quality.

dbanig@prflexbag.com

www.prflexbag.com

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

I am a trucker's wife. But I'm also a trucker. As such, I am in a unique position to know what it's like to be married to a truck driver AND what it's like to BE a truck driver.

Pallets are platforms that are used for transporting or storing things. They are used especially in industries like factories, warehouses, retail, food storage, grains, chemicals, pharmaceuticals, etc. Pallets are often placed in rough industrial conditions with high humidity, pollution, and dust levels. It is thus very important to use covers for protecting the pallets.

Finding a banker, financier, angel investor, or venture capital company to invest in your new business venture can be difficult. It is even more difficult if you do not present your management capabilities in a clear and precious manner.

Tags

Links

Digg It - Corona Surface Treatment Allows For Effective Printing On Plastic Film And Substrates

Related Articles: