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Undoubtedly, the most important property in the operation of electrical equipment is electromagnetism. It's the property of attraction an

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

d repulsion that enables motors, generators, solenoids, relays and other control equipment to function.

Magnets can be classified as per

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

manent or temporary by their ability to retain the magnetism. Normally, hardened steel or nickel-cobalt alloys are able to retain their m

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

gnetism indefinitely. These are called permanent magnets. In the electrical industry, they find many applications. Some of them are: elec

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

tric meters, magnetos, loudspeakers, and control switches. Because of its permanent nature, there are also many other uses not related to

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

industry.

The bulk of the uses in electrical equipment are the temporary magnets. When electrical direct current is passed through a coi

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

l surrounding a soft iron core, the latter becomes a magnet. When the current is removed, the coil loses its magnetism. Solenoid actuator

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

s and relays make use of this phenomenon to control circuits and other processes.

However, not all the magnetism is lost. A small part o

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

the magnetism still remains after the magnetising force is removed. To counter this effect, some of the magnetic cores are modified to r

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

educe the effect of these remaining magnetism. By enlarging the air gaps for some of the magnetic components, the forces coming from the

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

mall magnetism are rendered too weak to counter the forces of springs found in solenoid actuators and relays.

But this remaining magneti

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

sm, called residual magnetism, is important for the operation of DC generators. Electrical current is generated or induced in a wire only

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

when there is a movement relative to the magnetism. So without that first residual magnetism, there will not be any current induced.

In

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

fact, to start an electrical generator for the very first time, some magnetism must be present in the steel cores before it can produce e

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

lectricity by itself. Usually, the current will be injected in from electrochemical storage batteries. Once the generator is able to prod

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ce power by itself, some of it is fed back to the magnetic core to maintain that magnetism. Only when the soft steel core has acquired th

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

e residual magnetism, can the generator produce electricity each time it is started.

Understanding magnetic fields can enable us to desi

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

gn powerful electrical machines that can be used for the good of mankind. Where can it lead us? Perhaps to wonder!

Our mother earth itse

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

f is a giant magnet with its own North Pole and South Pole, where world travellers using magnetic compasses are able to determine their l

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ocation relative to them. Where are we in relation to attraction and repulsion of planets in the universe? Is it magnetism? Is it gravity

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Mergers and acquisitions are common terms used to refer to the amalgamation of companies. A merger results when two companies come together to form a single company. Mergers are similar to acquisitions, excluding that in mergers, existing stockholders of both companies maintain a shared interest in the new enlarged entity. The shareholding pattern may vary, depending on the valuation of companies concerned.

Business security is extremely important in this new era of increasing crime and is considered as a valued investment.

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