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When sourcing a new press brake the buyer's goal should be to match the equipment to their expected requirements and use, plus get the best value for their investment. This m

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

eans obtaining an excellent quality product with proper features at an affordable cost. Also, just looking at initial cost can sometime be deceiving as life cycle costs shoul

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

be accounted for that includes maintenance costs and efficiency of labor in using the press brake.

Hydraulic press brakes began replacing mechanical ones in the '70s due to

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

costs and safety issues. Mechanical components were replaced with a hydraulic system which eliminated these costly machined parts. Of course, incorporating a superior hydra

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

lic system with quality components is paramount to supplying reliable and accurate equipment for the end user. The buyer should also ask if valves, rings, seals and other key

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

hydraulic components are readily available and if the company they are buying from has a good after sales service staff. Proprietary parts are often difficult to find or can

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

take a while to obtain.

Press brakes, like all machines, have features that differ across the various manufacturers. The back gauge is a feature that is generally not includ

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ed with this machine as standard equipment even though it is extremely useful. This gauge is typically sold as an option. This is true also for tooling as well. There are spe

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ialty tooling companies that sell after market press brake tooling for all types of press brake jobs. Yet, a savvy buyer will be able to negotiate a front operated power back

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

gauge and tooling package to be included with their press brake purchase. If the supplier is on the cutting edge he will have either American or European style tooling to of

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

er to the customer.

Since the buyer usually has to rely on the salesman's recommendations, it is very important to buy from a dealer who not only is knowledgeable about meta

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

fabricating machinery, but also has some metallurgical background and common sense. When the customer says they want a 150 ton press brake for instance, the salesman needs t

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

o query them further and pin point the type of material they are going to be working with. Bending stainless steel requires 50% more power than bending 60,000 tensile plate f

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

r instance. The salesman should know that the term "mild steel" hasn't existed in over 20 years. This material was replaced with A36 and the tensile can range from 57,000 psi

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

up to 80,000 psi. There is a huge gap, so instead of figuring 15.4 tons per foot when bending ?" A36 material you need to kick it up to at least 19 tons per foot. Even tho

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

gh the end user may not have given enough information to the sales person, it is still up to the sales person to help match up the right equipment for the job by asking the r

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ight additional questions.

The buyer also needs to be certain that whichever press brake they purchases that it is flush floor mounted. Many of the 150 and 176 ton machines

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

n the market require a slot in the floor to accommodate the apron that hangs from the front end of the press brake. Sometimes the photo in a catalogue does not pick up this i

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ssue. Ask your sales person so that you don't become surprised and pay a lot more money for this type of foundation.

Purchasing press brakes is an important task; there are

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ome valuable tips that can go a long way in saving the buyer money and labor. Be sure to do your research and search for high quality equipment, as witnessed by this salesman

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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There are two principals that are effective in getting attention as well as delivering credibility for your advertising claims.

Human Resources personnel, professional recruiters and various other career experts all agree: one of the best ways to prepare yourself for a job interview is to anticipate questions, develop your answers, and practice, practice, practice.

Power fasteners are those that are specially designed to withstand extreme conditions and are made to rigid quality standards in order to perform a more efficient job of fastening. These fasteners are useful where other types of fasteners do not measure up for the job at hand.

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