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As the name suggests a Metal Detector is a kind of instrument, which is used to detect metal with the help of electromagnet

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ic induction. It helps in the detection of land mines, weapons like knives or guns at airports, in treasure hunting or in a

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

rcheology. It can also be helpful in detecting foreign bodies in food. Construction industries find it useful in detecting

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

steel reinforcing bars present in concretes, pipes, or wires in walls and floors. It can sense any electrically conductive

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

piece of metal. Metal detectors came into being around the end of the 19th century.

Metal detectors have many applications

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

. In archeology metal detectors are of good help. But in some countries like France and Sweden law prohibits metal detector

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

s, but with special permission it can be used. In spite of all these restrictions the contribution of metal detectors in th

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

s area cannot be denied. A good example is the utilization of these detectors to inspect wide areas like sites of battlefie

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

lds, where the only remains could be the surface, scattered with metal objects.

Some times people use consumer metal detec

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

tors to find coins on the beach as their hobby. Generally in the following types of hobbyist activities metal detectors are

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

used.

Coin Shooting, searching for coins, mainly old coins. Prospecting, searching for precious metals like gold or silv

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

er Relic Hunting, searching for any thing that has any historical significance, like weapons. Treasure Hunting, searching

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

for hidden items.

For security purpose metal detector are of great help. In airports this is used in great extent as it h

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

elps to detect any dangerous items carried by passengers that can cause harm to others, especially weapons,

One should kno

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

the right procedure of using a metal detector. Here are certain vital steps for using a metal detector:

The very first th

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ing, that is needed to take care of is tuning. This means the detector must be adjusted so that it can recognize the ground

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

as a channel for the targets to be inside. Sometimes however the devise posses a self tuning trait installed. After this o

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ne is ready to go for the search of the targets, coins, treasure or anything. The placement of the loop is also very import

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ant. To get the best functioning it should be held at arms length along with the loop and it should be barely above the gro

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

und and the loop must always be in motion for best result. While searching with the detector one should move at a slow pace

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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