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    A proposition: incompatibility is a product of competition.

    Recently I found this notification on the CBS site “Stati
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    stics Netherlands”:
    • Divorce rate up in 2005 Compared to 2004, the number of divorces in the Netherlands ro
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    e by nearly 2 thousand to 33 thousand in 2005. Incompatibility of characters and infidelity are most frequently mentio
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    ed as reasons for divorce...(Source: CBS - http://www.cbs.nl/en-GB/menu/themas/mens-maatschappij/bevolking/publica
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    ies/artikelen/2006-1862-wm.htm) - there is more interesting information about this topic, but that doesn't serve this
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    article -

    In order to compete, we know from Michael Porter and other strategist who have written about the
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    subject, companies tend to differentiate. And these minor differentiations end up in the products and services we (con
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    umers and other businesses) buy from them. The same differentiations that will make that one solution of on typical pr
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    duct or service will not cooperate – will not be compatible – with other similar solutions. When you travel from Europ
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    e to the US, your electrical plugs are incompatible. This particular case can be solved, but you need to be prepared,
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    ach time you face such a situation.

    On an individual level these mismatches also occur within companies. The way you
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    anage to communicate with your boss or with others is an indication of compatibilities of characters, although the ter
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    incompatibilities of characters could easily be misused. Being a professional you should be able to communicate with
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    everybody.

    Beyond the individual level though, there are many situations in a company where you may find incompatibil
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    ty. It is again the fierce internal competition that makes organizations sometimes inefficient. This becomes clear whe
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    – when the cost reduction programs enter the business stage – that synergies are hard to find, because of resources a
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    d different types of solutions that clash.

    Although it happens often, many employees meet and date others members fro
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    m the same company, it is not necessary that you get that close to others, but teamwork is not something that is put o
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    the management agenda because of no reason.

    Teamwork is necessary because of many reasons, one of them being able to
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    reach internal synergies; otherwise your company might as well split up in different competing units.

    © 2006 Hans Boo


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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