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    I witnessed some interesting behaviour from one of our premier management schools this summer. A behaviour that I have since discovered is not uncommon.

    This summer I met the PA of an emminent professor at a business school.

    I had met her on several occas
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    sions before and knew her to be a bright chatty woman who always enjoyed passing the time of day.

    On this occassion when I asked her how her week was going she looked at me and I could see that she wanted to smile but the muscles in her face would not work
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    nd after a few twitches she gave up trying and looked back at the ground.

    I asked her what was the matter and she told me that her department was undergoing change.

    I asked her what that actually meant.

    She told me that a "Change Manager" had appeared in
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    the department and everybody was waiting to see who got the sack.

    This was a woman, who is normally a capable and confident administrator, had been reduced to a nervous wreck because she perceived that an anonymous arbiter had been brought in to decide her
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    uture.

    This was her reaction to the presence of a "Change Manager" based on her perception that change meant people being sacked.

    How close was this perception to reality?

    I met my PA again a month later and the way that she and her colleagues had been tr
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    ated made me spit.

    She had got over her first shock and was now extremely angry with the college authorities.

    30 senior PA's were now involved.

    It seems that the chancellor and his senior team had announced the changes then brought in a consultant to rati
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    fy them.

    The situation for the PA's was that they had been told that their fates would be announced in six weeks.

    They had no idea how many jobs would be left after six weeks but were told that nobody would be made redundant, alternative employment would b
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    found.

    The perception of the PA's was that their managers had already decided how many would be let go and were only spinning it out under the guise of "Managed Change" because they wanted to pretend that the decision was part of a reasoned process and not
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    the arbitrary wielding of a financial axe by the accountant.

    It was awful to watch the diabolical way a centre for excellence was treating its own staff, and still had the temerity to continue to hold itself up as an example to whom we should look for lear
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    ed guidance.

    "What thickness is the ivory on their tower that prevents them seeing the consequences of their actions?"

    My initial question was whether this girls perception of change was shared by others.

    It seems that it is.

    I spoke to my PA friend agai
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    last month and they were still telling her to wait while the decision was made about her future.

    She could not endure the stress any longer and started to look for alternative employment.

    As she said, she loved the job that she used to have,

    The authorit
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    ies had through their actions caused her to lose trust in them and come to hate the job that was now causing her so much stress.

    She could not consider continuing to work for them even if they announced tomorrow that her job was safe because she could not c
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    ntinue to work for, or trust, people who had caused her so much pain.

    This behaviour from a respected university that is held up as a centre of management excellence is, in its personal effect on these individuals, appalling.

    It is interesting to note that
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    the bosses of all the PA's affected had by this time been asked to reapply for their jobs too.

    The PA that I know told me that her boss has started to look for work elsewhere for the same reasons as she had.

    Last week I met the PA again and she told me th
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    t both she and her boss had found new jobs, still working together, at a neighbouring school.

    It does not have the same reputation but that is a situation that neither of them thinks will last for very long.

    Having spent long hours discussing how diabolica
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    the action of the college was the PA's had come to realise that what was apparently just another example of Crass bad management was in actual fact best practice.

    As a centre of management excellence one of the techniques that was advocated to avoid making
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    redundancy payments when you need to get rid of people is too make the workplace so stressful that they choose to leave.

    The favourite technique for doing this is to make people reapply for their own jobs.

    I am happy to report in this instance that the ma
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    agement school were well and truly stuffed.

    My PA, and a number of others who had all found alternative employment, accidentally neglected to tell the college that they had found alternative employment.

    The result was that the college, when nobody left vol
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    untarily, were forced to announce the redundancies. Every single person made redundant took their payment then walked straight into a new job that they had already accepted.

    The college still had to make redundancy payments to the people it had always inte
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    ded laying off but in addition it also had the expense of recruiting new staff to fill all the other posts of the people who had left because of the shoddy way the college had treated their staff.

    What goes around, comes around.

    Score one for the good guys


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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