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The price of zipper plastic bags has been increasing for over a year. Hurricanes Katrina and Rita knocked out or severely damaged plastic manufacturers who produce key resins which

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

made the price climb even higher. Even though those events happened about a year ago, their effects can still be felt today. Further, with the instability in the Middle East, there

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

is no telling where the price of zipper plastic bags, also known as zip seal bags, will go as oil is a critical ingredient With this in mind here are 10 quick tips you can use to

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

minimize the impact on your operation and reduce your cost.

1. Experiment with different film thicknesses. Many companies feel they get better protection with a thicker bag. This

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

is not necessarily the case. The material used to make your zip seal bags determines the strength and barrier properties, not the thickness. Thicker does not necessarily mean bette

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

r.

2. Rely on your manufacturer of zipper plastic bags for guidance. These are unique times in the plastic industry and having the direction of your packaging professional can mak

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

a huge difference. Your packaging professional can help you determine the right film for each of your applications. Often, companies will use a one-size-fits-all approach for thei

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

r zip seal bags and they tend to spend more money than they need to.

3. Ask for a lead time in writing from your plastic bag manufacturer with your order confirmation. While this

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

on't guarantee when your zipper plastic bags will ship, a reputable firm can be fairly close in their estimate. Knowing when your zip seal bags are supposed to arrive will help you

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

manage your inventory and minimize any chance of running out.

4. Make contingency plans in case your plastic manufacturer cannot get resin for your zip seal bags. A few years ago

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

his was unheard of, but today this is a very real possibility. Your supplier should have back up plants they can go to in a pinch. Most importantly, discuss this with your packagin

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

professional. They need to know your zipper plastic bag needs so they can help you before you run out.

5. Consider different plastic film choices for your zip seal bags. Blendin

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

g different resins can increase the strength of your plastic bags and allow you to use a thinner plastic film.

6. Try using stock zipper plastic bags. There are many stock sizes a

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ailable which are run in extremely high volumes. You’ll save money when you can use stock zip seal bags instead of a custom size.

7. Order an additional month of material. Zipper

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

plastic bags take up a small amount of space compared to other packaging products. Ordering a slightly larger quantity will reduce the price of them as well.

8. Understand how to

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

determine the right size zip seal bags for your application. While this may sound obvious, many companies purchase zip seal bags much larger than they need. Rely on your plastic ba

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

g manufacturer and/or packaging professional for help.

9. Consider an Auto Replenishment Program. Have your supplier keep a certain number of zipper plastic bags on their floor at

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

all times. As soon as you release them, they’ll automatically run a new order for replenishment.

10. Consider ordering a blanket of zip seal bags and have your plastic bag manufac

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

turer run and hold them. This will lock in your pricing, minimize the lead time, and by committing to a larger order will reduce your total cost.

In closing, these tips are simple

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

o implement and put into action. It cannot be emphasized enough the importance of a trusted packaging professional to help guide you and your company through these challenging times

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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