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On 21st August 2006 the Royal Mail introduced a major change to the way in which postage is calculated within the UK. Called Pr

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

icing in Proportion the new system takes into account the size of the item as well as its weight. The size and thickness of an

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

rticle determine its format; letter, large letter, or packet. Each format hs its own schedule of weight-band charges.

You

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

can minimise your postal costs by understanding how the system works, and by employing the following strategies, you can exploit

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

it to make substantial savings on your direct mail campaigns.

1) Smaller is Cheaper

It now costs more to send an A4 siz

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

e letter. So fold the letter, put it in a DL or C5 envelopes and cut at least 12p from the postage cost per item.

2) Losing

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

eight Wastes Money

The weight bands applicable for each item format have been revised to create fewer, wider bands. For exa

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

mple the 0 to 60g band has been replaced by a 0 to 100g band. There are no rebates for weight allowances not used. So fill your

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

arketing envelopes with more information about your business, more leaflets, more promotional flyers, more vouchers etc. It cos

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ts the same to send a 100g letter as it does a 60g so fill ’em up!

3) The Word is “Flat”

The thickness of an ite

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

is now as important as its size and its weight. Putting bulky items like pens into envelopes will push items up into the next f

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

rmat, and increase the postage cost. So think carefully about what items you want to include in your mailings and promotions.

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

Flatter is cheaper.

4) More is Less

Using DL or C5 envelopes increases the range of Royal Mail bulk discount sc

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

emes available to you. These offer significant savings on postal costs. If you are planning direct mail campaigns make sure you

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

know the requirements for each service. These include item size, address accuracy, item weight and number of items.

If your ma

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ling meets the first three of these requirements consider increasing the number of items you plan to send. It may be well worth

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

your while. For example, you could save ?9.79 on a mailing of 999 letter format items sent 2nd class just by making it a maili

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

g of 1000 “Cleanmail” items and claiming the cheaper item rate.

Or you could save up to ?471.65 on a 2nd class C4 mailing of 39

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

99 items by making it a mailing of 4000 items.
Think bigger!

Pricing in Proportion is the biggest change in Royal M

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

il pricing for many years. Don’t shy away from it. Exploit it! Seize the opportunities! You can make it work to your advantage

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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The 3 main classes of Business and Investor Visa are some of the most straight forward visa's available for residency in Canada. This detailed overview explains whgat is required to apply and where to find the information.

We are in the midst of another wave of mergers. They fail far more often than they succeed. Here’s what to avoid and what to do to increase the odds in your favor.

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