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One of the few mementos that remained from my grandparent's estate was a deck of playing cards. The other was a finger 'nappie' cut glass

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

bowl signed by the artist. Their seven children shared equally the inheritance and not a stick of furniture came our way. No one knows

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

what happened to the collection of antique hand spun Christmas ornaments or which daughter in law got the Haviland china. I always meant

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

to keep the cards in the family to hand down to my daughter (she did get the nappie), but hard times made us desperate for money to pay th

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

bills.

A transformation deck dated 1871, these Tiffany cards were hand made. Scenes in and around the city and country depicted the var

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ious modes of clothing popular at the time. No two card were alike. People were dancing, skating, talking, shopping, walking their dogs,

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

and playing instruments. A clever pattern of diamonds, spades, clubs and hearts were worked into the scene to allow regular play amd pr

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

nted on a strong plastic for a good snap. They came with a custom leather case, stamped in gold with the owner's name (a relative). All

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

fiftytwo cards were present plus two jokers. These playing cards could not be bought, but were given as a bonus for buying a certain amo

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

unt of Tiffany wares in their New York store. I thought that somewhere a collector would love to own these unusual cards.

I discovered t

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

at the author of a book on the subject lived in a nearby town. I called and he said he would be glad to look at the cards. He glanced ca

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

sually at the cards, quickly replacing them on the cocktail table. He said that they were not worth more than two hundred fifty dollars.

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

I was surprised at the low amount, telling him of a story I read in a Life Magazine book on antiques that an exact deck was sold ten year

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

s previously for four hundred dollars. He said that he knew of that book and he believed it to be a misprint. Suspicious, I told him I wo

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ld think about it. He called several times, but I wouldn't change my mind.

Back at the library, I found a source book with a list of kno

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

wn card collectors. I wrote to four of them, one in England, one in South Carolina and two in a western state, describing the cards and a

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

sking for an offer. The South Carolina person replied with an excited request to buy the cards for one thousand dollars. She related tha

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

she belonged to an antique card club and that the president owned such a deck, but in poor condition. She admitted that they might be wo

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

rth more, but one thousand dollars is all the money she could spend. I wrote back that I would be glad to make her happy, not being a col

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

lector myself. Soon the certified check arrived, the cards were insured and sent off, the bills got paid and (almost) everybody was happy

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Some interesting facts which can help you in avoiding the chop in your workplace..

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