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The theory of Exponential numbers basically means that on a J-curve most of the growth happens towards the end

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

or that the size of the numbers very quickly increases at an exponential rate in certain types of observed grow

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

th.

Perhaps the most common example of a growth rate that grows began really slowly at first only to explode l

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ater on is the size of the total human population on earth. For thousands of years the number of humans was ne

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

arly static with only a very slow growth rate, however in the last couple of hundred years the growth rate has

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

exploded and the doubling time is shortening. The power of these numbers can be better understood when one rea

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

lizes that despite the length of human history if we added up all the individuals who ever lived by far the maj

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ority have lived in the last 200 years (if not even closer to 100 years) - despite the many thousands of years

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

before, the majority of people who have ever lived are likely to be living now.

A similar example is when you

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

theoretically (if it were possible) consider folding a piece of paper 50 times. How thick would that paper end

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

up? The fact is it would extend from here to the sun - the power of exponential numbers at work again.

So wha

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

t use is this knowledge to the average business operator on the internet? The fact is the power of exponential

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

numbers is at work all the time on the internet. Look at any popular site and look at the growth of its traff

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ic. Sites don't start at millions of hits a day, but over the years they can grow to that size. Where many fa

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

il on the internet is they are not willing to invest one of the most important internet commodities - no not mo

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ney - time! Even Google the inspiration for many would be net millionaires took time to grow. Although its ab

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

out 10 years old most of that growth occurred later in the J-curve, not in the first few years. Numerous other

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

examples occur online - ebay, article directories, forums, myspace, etc.

The moral - Don't get discouraged be

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

cause your traffic is not growing as fast as you like, so long as it is steadily increasing the power of expone

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ntial numbers can kick in. The secret is to get started as soon as possible, preferably before the competition

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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