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Top 30 aroma chemicals used in making fragrances Based on about 800 popular fragrance formulations, which are used in So

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

aps, Detergents, Toiletries, House-hold products, Incense sticks, Attars, etc, we are able to provide a tentative data of global consumption of

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

synthetic chemicals used in making fragrances.

The market data for Attars& Agarbatti is still not clear. The market data for the fragrance cons

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

umption for the regions like Middle East,Africa,some Asian region is also not clear.Hence,the data provided below gives some idea of global cons

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

mption of top thirty chemicals used in making fragrances.

We have also taken into account the global consumption of the raw materials used in m

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

anufacturing these products.

We have not considered terpenes like Alpha-pinene,Limonene, etc which are directly used in fragrances.

We have ta

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ken into account the fixatives& diluents into account as they form a major contributor in fragrance formulations.

There are about 40% of the sa

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

e chemicals also used in making flavours. Some of the chemicals like Vanillin, Menthol, Eugenol, Limonene, Esters of lowers alcohol, Esters of l

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ower fatty acids are as bulk as the chemicals mentioned below, but 80% of their global consumption goes in to making flavours. Hence we cannot c

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

onsider them in to the top thirty fragrance chemicals.

The following chemicals are manufactured from the raw materials, which are originated fr

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

m petrochemical source or natural source. Some of the products mentioned below are also used in polymers, drugs, pesticides, etc. Hence,the glob

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

al consumption of such chemicals are much higher than what is mentioned below.

The following data concerns only with their consumption in fragr

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ances.

1] LINALOOL& ITS ESTERS -8000 TONS

2] GERANIOL& ITS ESTERS -1200O TONS

3] TERPINEOL& ITS ESTERS -8400 TONS

4] ISO-E-SUPER -6000 TONS

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

5] GALAXOLIDE -4500 TONS

6] BENZYL ACETATE -12000 TONS

7] DIHYDROMYRCENOL&DERIVATIVES -8000 TONS

8] LYRAL -4000 TONS

9] BENZYL SALISYLATE -

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

000 TONS

10] DEP -20000 TONS

11] AMYL & HEXYL SALISYLATE -3000 TONS

12] HEDIONE -8000 TONS

13] PHENYL ETHYL ALCOHOL,ESTERS,ETHERS -14000 TON

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

S

14] BENZYL BENZOATE -4000 TONS

15] CITRONELLOL& ITS ESTERS -6000 TONS

16] ISOLONGIFOLINE DERIVATIVES -2500 TONS

17] NITRO MUSKS -2000 TONS

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

18] CEDRYL METHYL KETONE,ACETATE & METHYL ETHER-3000 TONS

19] LILAL -5000 TONS

20] IONONES-BETA& ALPHA,GAMMA METHYL IONONE -12000 TONS

21]

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ERANYL NITRILE& CITRONELLYL NITRILE -5000 TONS

22] PTBCHA& OTBCHA -10000 TONS

23] ANISIC ALDEHYDE,ANISIC ALCOHOL& ESTERS -3000 TONS

24] IBCH&

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ICCH -3000 TONS

25] TONALIDE -3000 TONS

26] CINNAMICALEHYDE,CINNAMIC ALCOHOL&ESTERS -3000 TONS

26] COUMARIN & DERIVATIVES -2000 TONS

27] NA

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

PHTHYL ETHERS -2600 TONS

28] DCPD ESTERS & DERIVATIVES -3000 TONS

29] ISOPROPYL MYRISTATE -2000 TONS

30] DIPROPYLENE GLYCOL& ESTERS -2500 TON

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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