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Digg It - Trapped in a Box: The History of Carton Revealed
We may not be aware of it but the simplest of materials we use for covering our food has been around for over centuries. Take a peek inside your pantry and try to see if
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
you can find a milk carton, a carton full of eggs or even a carton of your favorite breakfast cereal.
Indeed, this centuries old packaging material is the carton.
Car
Indeed, this centuries old packaging material is the carton.
Car
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
on is often made out of a composite or of materials made out of two or more components. Cartons can be made out of a mixture of paper, pulp, wood or leaves. Its durabili
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
y and stiffness makes it ideal for packaging heavy materials.
The carton has existed even before food manufacturers have used it for carrying eggs, milk, cereals, bakin
The carton has existed even before food manufacturers have used it for carrying eggs, milk, cereals, bakin
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
powder and other types of food. Although there have been a lot of materials discovered and used for wrapping and encasing, the carton still remains one of the most ofte
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
used for packaging.
The carton first appeared in the 15th century in China and served different purposes. However, the first commercial carton was not used up until th
The carton first appeared in the 15th century in China and served different purposes. However, the first commercial carton was not used up until th
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
1817 when it was first produced in England.
The durable and sturdy carton that we know of today, on the other hand, would not have even existed if English hat makers i
The durable and sturdy carton that we know of today, on the other hand, would not have even existed if English hat makers i
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
n 1856 did not think of using it to line the bases of the hats they made. In fact, before this, carton was just a flimsy, thin type of paper that was not even considered
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
to use for packaging.
The corrugated carton is the type of carton that has pleats attached to sheets of carton. These pleats of carton serve as support for carton sheet
The corrugated carton is the type of carton that has pleats attached to sheets of carton. These pleats of carton serve as support for carton sheet
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
as it makes it more rigid and suitable for carrying weighty materials.
When the first corrugated cardboard was patented in 1856, it was mainly used in England for the
When the first corrugated cardboard was patented in 1856, it was mainly used in England for the
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
ases of tall hats that were of fashion to English gentlemen.
It was only in December 20, 1871 when Albert Jones of New York, New York filed the patent for the corrugate
It was only in December 20, 1871 when Albert Jones of New York, New York filed the patent for the corrugate
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
carton. However, the corrugated carton Albert Jones patented back then only had a single-sided sheet of carton with the pleats attached to it.
The corrugated carton, f
The corrugated carton, f
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
om which the modern corrugated carton would be based from, was not produced up until 1874. During this time, Oliver Long, took Jones’ design and incorporated another she
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
t to make it more stiff and suitable for packaging heavier materials.
Now bear in mind that these cartons were just sheets and were not yet the carton boxes that we kno
Now bear in mind that these cartons were just sheets and were not yet the carton boxes that we kno
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
w of today.
In 1890, an American named Robert Gait “accidentally” invented the corrugated carton box. Robert Gait was a printer and paper bag maker. While printing an o
In 1890, an American named Robert Gait “accidentally” invented the corrugated carton box. Robert Gait was a printer and paper bag maker. While printing an o
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
der of seed bags, the metal ruler used to crease the bags swung and cut the bags instead.
Through this, Gait discovered that creasing and cutting the bags would make it
Through this, Gait discovered that creasing and cutting the bags would make it
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
easier for manufacturers to make pre-constructed cartons.
Instead of using the seed bags that he was printing on, he creased and cut corrugated cartons instead. So when
Instead of using the seed bags that he was printing on, he creased and cut corrugated cartons instead. So when
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
the 20th century rolled in, wooden crates were replaced by cardboard boxes made out of corrugated carton.
Today’s corrugated cartons are more intricately designed than
Today’s corrugated cartons are more intricately designed than
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
hose of the cartons used in earlier centuries. At present, the outer sheets are made to be puncture resistant. The pleats are also made up of a stronger wood-based type
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
f paper to make the cartons sturdier and compression resistant.
Who would have thought that a piece of carton used to hold your day’s breakfast can have so much history
Who would have thought that a piece of carton used to hold your day’s breakfast can have so much history
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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