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Boni Comandante from Dumagete City Philippines discovered how fish can hi

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

bernate from six hours to twenty four hours thus being able to transport

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ive fish cheaply and effectively.

He discovered how fish can hibernate w

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ile in Palawan. Comandante threw a fish in an ice chest and six hours lat

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

er he saw the fish in a suspended state. At that moment he knew that what

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

he just witnessed means big bucks. But it took him fourteen years to full

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

develop his discovery. In 2004 he won a competition by DTI [Department o

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

f Trade and Industry] and later was able to attract local and foreign inv

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

stors for his fish marketing business.

He called his technique of puttin

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

fishes in a suspended state— Buhi Technology. The fishes are preserved l

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

nger and are less stressed because of the absence of water. The tail and

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

the fins of hibernating fishes lie flat while transporting it and then ar

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

later on revived with sea water. Another good thing about Mr. Comandante

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

s method is that it reduces the cost of ice and water which cuts up to se

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

venty five percent of delivery cost.

There is no need to worry about saf

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ty, the Bureau of Fishers and Aquatic Resources declared that the fishes

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

re safe for human consumption because all the materials used are organic.

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

This is certainly good news for Filipino fisher folks as the demand for

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

live fish is growing here and around the world, and with the help of Buhi

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

technology a boom in the fishing industry might just be around the corner

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Technology represents only one part of the mix. It can never replace personal contact.

Twenty-five percent of employees suffer with peer to peer bullying and its on the rise, according to the National Institute of Safety and Health. Dina Beach Lynch, a 12 year workplace strategist and mediator, has the answer: Conflict Coaching. A short-term, results-oriented tool, conflict coaching enables employers to quickly, skillfully manage bullying before it escalates into complaints and harrassment charges.

Ensuring the success of any book is something even the biggest publishers have never been able to guarantee, but with a good book, a little or a lot of money, and just plain hard work the odds are in your favor; many have done it.

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