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In the early pre-production stages of my making ‘Cobra’s Wish’, I came across some great obstacles, one of them being how to find the right team to shoo

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

t this movie. Friends and acquaintances gave me all kinds of suggestions.

I tried Mandy.com and Craig’s list. Of all the resumes of the cast and crew

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

I received I had to choose the best to fit my budget. I had to consider a number of factors:

1. Find people who do the best job possible technically

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

2. Complete the shoot within the allotted time

3. Audio and video to be in a good shape for editing so the final cut will look decent.

4. People who ca

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

work well together as a team.

One thing, in my opinion, most people ignore is the chemistry among the cast and crew members. But not only that. If

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

he line producer does not see eye-to-eye with the director, the shots will not look so great.

Lack of chemistry and personality clashes can lead to fin

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ncial loss and failure, as we have seen with the Disney Company where the two top executives Michael Eisner and Michael Ovitz were at constant loggerh

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ads. Eventually Ovitz got fired costing Disney $140 million dollars in severance pay. The astrological charts of Geena Davis and Donald Sutherland i

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

dicated to me that the TV show Commander-in-Chief on ABC would not make it.. There was further trouble when creator Rod Lurie missed script deadlines a

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

d caused production delays. Harmony and good chemistry among cast and crew is essential to make a movie or TV series a success.

In some of the classic

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

like Sergio Leone’s The Good, the Bad and the Ugly the three main characters, Eli Wallach, Clint Eastwood and Lee Van Cleef had great chemistry and th

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

at’s why it has

been such a success. In Funny Girl we see great chemistry between Ormar Sharif and Barbra Streisand and in Meet Joe Black Anthony Hopki

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

s did an excellent job working with Brad Pitt. In the TV series Honeymooners a great chemistry existed between Art Carney and Jackie Gleason. And the

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

series has been admired by viewers for a long period of time.

It is also imperative that the director not tinge the movie with his/her own philosophy.

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

The spirit of the script must retain its essence in the final cut. To create conditions in which the writer, director and the crew can practically de

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ict the essentials of the story is the key.

To achieve this aim the personalities of the writer, director and line producer must harmonize. I did th

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

s astrologically. And everything turned out ok. One word of caution. No one except me (the writer) actually knew how I envisioned the entire movie in

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

my mind’s eye. This created a misunderstanding. Only when completed, the whole picture made sense because all the parts were in the right place.

And

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

this is how I won my Waterloo.

If you are in the process of finding the right team, it is important not to sacrifice the quality of production because

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

f a lack of funds. Make sure that crew members are in harmony and dedicated. and you’ll have a product you can be proud of.

Good luck with moviemaking

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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