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While the most common type of thermoformed packaging for industrial applications is a heavy duty thermoformed tray, other options include clamshells, lids for re

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

turnable sleeve packs made from plastic corrugated, and pallets. Whichever you choose to use depends entirely upon what you want it to do. Choosing a method that

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

conforms specifically to your needs can help save money in the long run, since your product will be packaged according to exact specifications. Here is a list o

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

f some other ways to save money using heavy gauge thermoforming:

1. Before placing an order, provide a sample of the product to be packaged to your supplier. Th

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

s way, your supplier can design trays that meet the exact specifications of your product. You’ll also get a more accurate, better-designed initial quote.

2. Pla

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

n ahead. Because thermoformed trays are typically custom-made, it can take a bit longer to fill an order. If you wait until the last minute to order, you will in

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

cur a lot of charges that could be avoided if you planned ahead.

3. Determine whether or not you can stack additional weight on top of your product. If this is

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ossible, your thermoformed trays will not need to be as deep. This means smaller trays made with less plastic, which means a substantial cost savings for you.

4

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

. Order thermoformed trays that are stackable and nestable, so they will stack on top of each other when loaded with product, and nest inside each other when emp

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ty. These take up less space, are easier to store, and also can help save money on shipping costs.

5. Have trays marked with a one-inch stripe on their sides. T

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

is will help operators identify when a tray is fully loaded or empty, which can save time and labor costs.

6. Before production, ask for concept sketches and di

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

mensions of your thermoformed trays. This way, everyone will be clear on what is required versus what is being ordered and produced. It there is an error, it is

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

easier to fix during concept design rather than after the returnable packaging is already produced.

7. Make a production tool instead of a wood prototype tool f

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

or thermoformed trays. Prototype tooling is time consuming – it can take up to two weeks! Production tooling can be modified and adjusted, speeding up overall de

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ign and production time. This also saves from having to pay the additional cost of a wooden prototype, which is completely useless after the job is completed.

8

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

. Once tooling is complete, evaluate plastic thicknesses by having thermoformed tray samples made. If your product can be supported by a thinner material, save m

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

oney by ordering thinner plastic.

9. Stamp thermoformed trays with an identification mark with company name, address, phone number, and other important informat

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

on. This will ensure the returnable packaging is returned to the correct address.

10. When you no longer need your thermoformed trays or they become obsolete, a

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

sk suppliers to buy them back for recycling. The price paid will be a scrap value, but anything is better than nothing!

In closing, heavy gauge thermoforming is

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

a cost effective and efficient form of returnable packaging. These tips will help you communicate with your packaging producer and keep your costs to a minimum

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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