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Children’s annuals are perennial Christmas best-sellers - of thousands of each title issued each year, most are read, and few remain in

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

collectible condition (perfect corners, no bent pages, all pages intact). Time wreaks havoc on condition of most books especially chi

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ldren's titles so snap up any you find in decent condition at boot sales, auction or jumble sales.

This means those that do remain int

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

act often fetch record breaking prices on eBay. But, surprisingly, that doesn’t make it difficult to find quality vintage children’s a

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

nnuals priced in pennies at boot sales and jumble sales which are highly valued collectibles on eBay.

Some amazing second-hand bargain

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

are possible especially in the run up to Christmas when families are clearing bookshelves to make way for next year's annuals. Innoce

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ntly many will also deplete their shelves of valuable vintage items. For example, avid Rupert Bear fan, Peter Blackburn told Collectib

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

les magazine about a 1937 Rupert annual he found at a boot sale for ‘a few pence’ which is worth $4000-6,000!

On eBay you’ll find Rupe

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

rt annuals high up in the final price listings but there are others which, featuring characters who are now icons in their own right, c

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

an fetch much higher prices. Examples are Bonzo Dog, Mickey Mouse, Felix the Cat.

Even somewhat damaged copies of high demand annuals

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

are still worth buying to resell, if they’re going cheap.

When you find them, take are of them, don’t risk reducing their value before

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

listing them on eBay.

TIPS TO HELP YOU MAKE BIG PROFITS SELLING CHILDREN’S ANNUALS ON EBAY

* Store annuals somewhere safe away from

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

damp and out of strong sunlight which cause foxing and fading.

* Writing and scribbling in books reduces value considerably. A nota

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

tion, usually in the front of books, such as indicating the book was given as a present or, with the original owner's name, is usually

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

acceptable.

* Look for and exploit reasons a book normally worth about $10 might be worth $1,000 plus - autographs, limited editions,

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

notable owner - a friend’s Beatles 1963 album (catalogue value $10) autographed by the group, has been valued at $2,000.

* Take a ris

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

on annuals costing less than a dollar apiece and expect some miracle finds. Focus on pre-1950 kiddies’ annuals, such as Rupert Bear,

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

Bonzo Dog, Desperate Dan, Mickey Mouse. There’s no saying how much these are worth in good condition, and bidding wars are frequent be

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

tween just one or two collectors desperate to add another title to their collection.

* At bargain sales don’t look too enthusiastic w

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

hen you find a bargain and be careful not to be spotted or you might give the game away and the seller could remove the book from sale

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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This isn’t about shy people - this is about ALL people. These facts represent the true nature of confidence as a function of self-limiting beliefs. It reminds me of great quotation by my favorite author, Anonymous, “If you put a small value upon yourself, rest assured that the world will not raise your price.”

There are two types of trade show display manufactures that you must be aware of. Some of them simply take pre-built display systems that could be pop-up, panel, or any of the other kinds and then customize them with certain graphics or other accessories that a customer might require. On the other hand, for those companies that have more specific requirements for their trade show display, there are custom display booth manufacturers who first design a display system in tandem with you and then build it from complete scratch. These kinds of booths are much more costly and are also typically only bought by companies that are quite large and who also attend trade shows regularly.

I am not a big fisherman, but I do enjoy it whenever the opportunity comes my way. I have some friends who are fanatics and occasionally I will go out with one of them. They have nice boats and it ...

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