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When Internet radio first began, about all a listener could do with it was, well, listen. And the listening experience wasn't very good. The

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

sound was awful ... when it worked at all. Having the audio stream abruptly terminate, or take endless time to re-buffer, was a common occur

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ence.

Today, most Internet broadcasters use much better technology to send their streams into cyberspace. As well, more listeners are equipp

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

d with broadband Internet connections, good sound cards, stereo system-quality speakers and sophisticated media player software.

The listenin

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

problem has been overcome.

Now, what about the ability for a listener to capture those audio streams and save them to play back at will? Th

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

technology to do that was slower in coming, but it's finally here. With the right program installed, you can now capture those live audio st

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

eams from your favorite Web radio broadcasters and save them to your hard drive to enjoy as often as you like.

There are now several sharewar

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

and even freeware programs available for recording streaming audio. Their names include Voice Activation Interface, WMA/MP3 Recorder, Audio

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ecord Wizard, Advanced MP3-WMA Recorder, Silent Bob, #1 Sound Recorder, Ace-High MP3 Recorder, 1st Easy Recorder, Visual Sound Recorder, Audio

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ib MP3 Recorder, Audio Playback Recorder, Loop Recorder, Replay Radio, FairStars Recorder, Boombox Internet Radio Player, and Easy Radio.

As

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ou might guess, these programs vary greatly in both ease of use and in the features they sport. Some can convert an audio capture into a larg

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

number of different music file formats, while others can only handle one or two. Some, but definitely not all, will automatically remove noi

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

e and hiss from the audio. Similarly, some will remove gaps caused by buffering or network congestion.

One of the first, and still one of th

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

best, audio capture programs is called Total Recorder. It can record PC audio from almost any source, including streamed audio, CDs, the com

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

uter microphone and other input lines.

You can download a free evaluation copy of Total Recorder, but it will insert a bit of noise about eve

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

y 60 seconds throughout the recording. To be able to record audio without the noise, you must purchase a license for the software.

The recor

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ing software that I find really exciting is the kind that not only will capture an audio stream, but will also save it as separate audio files

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

... automatically. The most obvious use for this is to break up a music stream into individual song mp3 files. The best audio capture softwa

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

e that I know of, that includes this mp3 splitting feature, is called Radio2MP3.

Internet radio has finally come into its own. The sound is

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

reat and so is the diversity of programming. Being able to record all those wonderful radio streams is the icing on an aurally delicious cake

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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