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Would you believe that there was a time that the internet didn’t have any domain names? During those days the internet was very much like a telephone network. If y

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ou wanted to visit a site, you would have to type that site IP address. And without domain names, visiting other websites became a chore.

In the olden days of com

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

puting, websites went by their IP address. So a particular site might be accessed by typing its IP address on the browser like so: “200.221.0.183” If you miss a nu

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

mber, and fail to notice it, you could get connected to a totally different machine.

The beauty of domain names is this: it allows the user to use a language frie

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ndly text address instead of complicated numbers. This text address is called the domain name. Computers need to communicate using these numbers.

But these number

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

s are confusing to humans because we don’t talk that way. A system called the DNS (Domain Name System) takes the domain name you type in the browser and looks up t

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

he corresponding IP address for that domain name.

Domain names usually have two or more parts, or labels, which are separated by dots. The rightmost part of the d

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

omain name is the TLD top level domain. This is symbolized by a 3 letter marker: ‘com’ for companies, ‘net’ for networks, ‘org’ for organizations, ‘edu’ for educat

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ional institutions, ‘mil’ for military, and ‘gov’ for governments.

Lately there have been additions to the top level domains; the most notable among them is the ‘

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

biz’ top level domain. Sometimes a CLD or country level domain is added further right to the top level domain. These domains are a two letter representation of the

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

country the site represents. For example: xxxxx.com.au.

The .com is the top level domain; the .au means that the site is Australian. The xxxxx is the domain name

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

, or subdomain name, depending on whether there are other non-TLD and non-CLD labels on the domain name.

Domain names do not belong to anyone, except for the NIC

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

or Network Information Centre. In theory, anyone could use a domain name. However, you would still have to pay for the handling of the domain name registration. Do

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

main names are not sold, they are leased. After the lease is over, other people interested in that domain name may apply for its lease too.

History

It was the AR

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

PAnet (Advanced Research Projects Agency Network) that developed the idea of using a more human-legible address for sites over the internet as opposed to machine I

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

P number.

Originally, each computer on the network would download a file called hosts.txt. This file would help the computer map domain names against their actual

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

IP addresses. This system, fact is still used in network systems such as the Windows OS.

As time passed by, the networking world reached a consensus that an inte

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

rnational organization to maintain and monitor these maps. In 1983 Paul Mockapetris invented the DNS. This is the same system we use today.

Domain names have made

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

surfing the World Wide Web easier. It has been said in many academic circles that the DNS is responsible for making the internet user-friendly and accessible to e

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

veryone.

This lead to the dramatic explosion in popularity of the internet. Now everybody can use the internet without having to be a rocket scientist or a genius

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

HTTP = HTML link (for blogs, profiles,phorums):
<a href="http://www.diggit.org.ua/article/59434/diggit-Domains-Your-Friendly-Address-on-the-Internet.html">Domains: Your Friendly Address on the Internet</a>

BB link (for phorums):
[url=http://www.diggit.org.ua/article/59434/diggit-Domains-Your-Friendly-Address-on-the-Internet.html]Domains: Your Friendly Address on the Internet[/url]

The sales pitch for interactive voice response (IVR) is very compelling - being able to offer 24-hour service to customers without human intervention. However, a large number of IVR applications fail to work well. Jonty Pearce looks at seven of the greatest sins!

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If you want to increase traffic to your online business or website you might want to try using a blog as an advertising tool. Blogging is something that has been around for nearly as long as the internet and it is only gaining in popularity and use

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