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In the online world, merchants usually have an alternative to signature for authenticating credit card transactions. Currently there are 2 methods, the CV

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

V (Credit Verification Value) and the AVS (Address Verification System). This article will explore each one of these methods, and will give you an idea an

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

d an opinion about which one is the best.

AVS, or Address Verification System, is a method to authenticate a credit card purchase based on the billing ad

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ress. The billing address supplied should be the same address that is displayed on the credit card bill. The security protection of this method is obvious

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

, as usually credit card fraud happens from another country overseas, where the person using the credit card has only the credit card number, and nothing

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

lse. The problem is, however, that this method can block legitimate purchases, as people often mistype their address, or in some cases, they change their

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

address, and the credit card information is not fully updated or propagated. What's even worse is that the banks, in case of an AVS error, put a 72 hour h

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ld on the amount of the transaction (so imagine the magnitude of this if a legitimate client had multiple AVS errors, which usually the case). Additionall

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

y, it seems that some transactions are not authenticated against the AVS at all. I remember one transaction that I saw that had "123 Go Away" as the addre

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

s and yet it was authenticated.

On the other hand, CVV, or Credit Verification Value, is a method to authenticate a credit card purchase based on the 3-4

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

digit number that appears on the back (VISA, MasterCard, Discover) or on the front (AMEX) of the credit card. Usually only the person holding this credit

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

card has access to this number (Credit Card companies have strict rules against saving the CVV in the merchant's database). The advantage of the CVV is t

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

at it's a number, and it's written on the credit card itself, so it's very easy for the people to type it in, and the error margin is usually low. What's

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

more exciting is that the CVV authentication nearly reduces fraud to 0, as it's very rare for the person committing the fraud to have the CVV (unless, of

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ourse, the credit card is stolen and not yet reported). The only disadvantage of the CVV is that some people don't even know where to find it; however, al

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

most all purchase forms right now have a small picture illustrating where to find the CVV. Keep in mind that the policy of holding the money in case of a

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ailed purchased also applies to transactions authenticated against the CVV, nevertheless, the magnitude of this is negligible compared to that of the AVS,

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

as people tend to make much less mistakes when writing a 3-4 digit number than to writing a complete address.

So which way to go? CVV or AVS? The answer

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

is clear, use CVV; it's simply less headache and more sales. Keep on asking for the address (do not verify for it, however), and always log the IP of the

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

transaction; in case you have the billing address in the US and the IP of the transaction is originating somewhere overseas, then most likely it's a fraud

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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