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Pay Attention to Bounces and Why

When an email bounces, it has not been able to be d

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

elivered. Most email providers will give you a reason for the bounces and by studying these

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

reasons, you can become better at avoiding bounces.

Here is a list of potential bounce reas

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ns:

1) Hard bounces. A hard bounce occurs when the email address or the email provider is

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

no longer active.

2) Soft bounces. A soft bounce is an email that was not able to be deli

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

vered, but possibly can be in the future.

3) Transient mail bounce. A Transient mail boun

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e is when the server is still trying to deliver the email but is having trouble doing so.

4

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

General mail bounce. In the case of the general mail bounce, it may be a hard bounce or a

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

soft bounce, but the provider has not distinguished it for you.

5) Blocked mail bounce. A

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

blocked mail bounce occurs when the receiver has bloecked your email address from deliverin

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

emails.

6) Out of Office/Autoreply. An out of office or autoreply simply means that the

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ntended recipient is not using their email temporarily, is simply alerting you that the emai

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

may not be read immediately, or will be back to it shortly – many times the bounce email wi

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ll give you a date or time.

7) Virus notification. With a virus notification, something i

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

your email has triggered the virus protection of the recipient to indicate that the email m

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

y have a harmful virus.

8) Change of email notification. A change of email notification e

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ail simply means that the recipient has a new email address; this can generally be rectified

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

with little effort.

9) Mail spam challenge. A mail spam challenge will ask you to verify

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

the email you are sending to verify that you are not sending bulk unsolicited email. Simply

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

follow the directions on the email and you should have your emails delivered to that address

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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