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When it's time to select your e-news distribution method, I recommend that you use a web-based provider. Such services are easy to use and quite inexpensive. Advantages of using an outside service provider over sendin

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

g your own e-news out are:

It is much less labor intensive.
You won't be accused of spamming by your ISP.
Distribution is fast and won't hog your computer's resources.
You get

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

reports on bounces and user response.

I advise against sending out your e-news yourself if you do not have a full-time technology staffer on hand. Even if you do, you run the risk of be

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

ng identified as a spammer and having your organization's domain name (that means all emails from your organization, not just your e-newsletter) filtered. It's far better to outsource your e-newsletter distribution to

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

a provider that is 100%-focused on deliverability (getting your e-news through to readers).

Before you start searching for the right provider, you need to define what you're looking for. Common features you'll want t

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

include are the ability to easily move your database of emails and names in and out, opt-in set-up, reader tracking information, bounce management, ability to segment your list and personalization. You'll also need t

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

estimate number of recipients and distribution frequency to ballpark service provider fees.

Here are a few tips:

1. Solicit recommendations on e-newsletter service providers from colleagues, based on your own param

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

eters.

2. Research other providers and get additional input on those recommended.

I'm considering the following providers as a result of my research:

Intelli Contact - User-friendly and fairly priced. Ve

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

y focused on ensuring deliverability to e-news subscribers.

http://www.intellicontact.com/index.pl

Constant Contact - Also easy and fairl

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

priced with a few less features. Good customer support.

http://www.constantcontact.com

BrontoMail - More expensive but offers other tools such

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

as e-survey distribution to e-news subscribers. Very service oriented.

http://www.brontomail.com

3. Focus on these Critical Facto

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Ease of Use - It should be straightforward and fairly quick to import your mailing database, manage your list online, create and send e-newsletters and review results.

Deliver

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

bility - Ask prospective providers what they do to ensure the highest probability of e-news receipt. Ideally, they will maintain a strict anti-spam policy, build relationships and feedback loops with major ISPs and ge

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

on white lists (lists of approved email addresses) to ensure your e-news is delivered. Ask what kind of information you get on bounces and how bounces are handled. You'll want to know which email addresses are hard

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

bounces (the address no longer exists) and which are soft bounces (undeliverable at the present time).

Reliability - Make sure your provider has a track record of reliable service. Ask f

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

r references or statistics to prove it. Your organization has too much to lose if something happens -- your email list gets copied or your newsletter goes out looking very different that the way you previewed it.

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

Flexibility - You may want to switch from text to HTML format at some point, to send both for different purposes or to segment your email addresses by state or title.

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

i> Tracking - One of the greatest benefits of e-newsletters is generation of quantifiable results. Make sure your e-newsletter provider tracks how many people (and who) get it, open it and/or click through to your web

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ite.

Pricing - Usually a monthly fee based on size of your list and/or number of emails sent. Some providers also charge a modest one-time set-up fee. Constant Contact charges $50/month fo

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

2,500-5,000 readers to whom you can send an unlimited number of emails. Intelli Contact charges $25/month for unlimited emails to 2,501-5,000 readers. BrontoMail charges $150/month for up to 5,000 readers.

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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