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Question: How can you disseminate a graphically interesting, beautifully designed small book to a large number of people cheaply? Answer: Email a PDF.

Almost every computer has Adobe Reader (formerly called Acrobat Reader) and PDFs are widely used as a way to present information wit

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

h a fixed layout similar to a paper publication.

Question: Why make a PDF newsletter? Answer: It’s cheap. Why pay for printing when you can get you readers to do it themselves?

The advantages of PDF publishing over internet publishing are:

No need to worry about browser o

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

r platform differences or complying to standards – if you can view a PDF properly in Reader the chances are that everyone else in the world can.

You can use any font you want.

Vector graphics appear pin sharp at any magnification.

You don’t need an internet connecti

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

on to read or print it.

PDF newsletterAh, I hear you say, the web is interactive but PDFs aren’t. Wrong again! So you want to make a cool, interactive, screen resolution PDF for emailing to multiple readers? How? Use Adobe InDesign. Obvious, I know, but you wouldn’t believe how many peop

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

le are still trying to do it in Quark.

Format, body copy and image

Landscape, portrait or square. It’s your call. I know what I prefer – landscape all the way. The perfect format to go for is A4 in the UK and Letter in the US so it prints out on everybody’s printers and a horizontal orientation (

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

on it’s side) so it fills the monitor.

No need for spreads so leave Facing Pages unchecked in the New Document dialog box in InDesign. Set some columns and margins if you wish, leave bleed at zero, and let’s get going…

Always design for the lowest common denominator. So if your PDF is being read

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

on a 15-inch screen then you will have the type at 12 point at least. Prefer vector graphics to bitmapped images as they will appear sharp and smooth at any magnification on the PDF. Keep images RGB and make them as colourful as possible. And don’t be afraid to use large high resolution files for t

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

he bitmapped images, they’ll be made smaller when the PDF is exported.

Navigation

One of the first things you need to do is to set up a master page. Master pages are used for elements that need to be repeated on multiple pages, for example page numbers, headers and footers.

In a PDF newsletter y

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ou may want the newsletter’s name repeated top left or right, a “home” button to return to the contents page or a couple of arrows to go to the next or the previous page. All these elements should be put in the master page. Do it here once and it’ll be repeated throughout the whole document.

Here

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

we must use InDesign’s powerful interactive tools. I find it’s better to make buttons with no fill and no stroke. Either choose a button from the toolbar or an empty rectangle and go Object > Interactive > Convert to Button. It works the same way. Do not use an element such as picture or text to ma

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ke interactive.

Double click your button with the Selection Tool or go Object > Interactive > Button Options… with your button selected and you will get the all important Button Options dialog box.

In this dialog box you will see two tabs. The first is General. Here you have three fields. The fir

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

st is name, this is for you – give it a name. The second is description, this is for your readers – it is the tip that appears when their mouse hovers over the button. So, depending on what the button is, put in a handy navigational tip like “go to contents page”. Finally, choose Visible for your V

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

isibility in PDF.

The second tab is Behaviours where you will see two drop down menus. On the Event drop down menu, I choose Mouse Up. This is for when people have clicked down on the button and then released, whereas Mouse Down is for when they have only clicked down.

The second drop down menu i

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

s the Behaviour – what’ll happen when the button is clicked. Here you can select one of 15 different actions.

Select the Behaviour you want, click Add (very important) and OK, and your Behaviour has been set. For Exit, Close, Go To First Page, Go To Last Page, Go To Next Page and Go To Last Page t

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

his is all you have to do. For every page you use in your InDesign document and the resulting PDF this interactivity will work beautifully. For navigation and interactivity: Do it in InDesign, don’t do it in Acrobat Professional.

Setting Bookmarks

For setting a Button Behaviour to go to a certain

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

page you need to set an Bookmarks in your InDesign document. This is very easy!

Pick the page in the main body of your InDesign document that you want to set as your anchor by double clicking on it in the Pages palette. In the Bookmarks palette (go Window > Interactive > Bookmarks) make a new Boo

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

kmark either by clicking on the arrow on the palette and choosing New Bookmark or by clicking on the Create New Bookmark icon at the bottom. Give your Bookmark a memorable name.

Then when you are setting the Behaviour of a Button you choose Go To Anchor and select the Bookmark you require (and the

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

zoom).

Now this will work even if you move the pages around in your InDesign document and if you double click on a Bookmark in the Bookmarks palette InDesign will jump to that page while you’re designing, making it a handy navigational tool of its own!

Exporting the PDF

When you are exporting t

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

he PDF direct from InDesign choose the Smallest File Size preset. In Options, make sure you have Optimize for Fast Web View checked. In Include, make sure you have Hyperlinks and Interactive Elements checked. You may like to check your Bookmarks as well.

In Compression, you may want to Downsample

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

the Color and Greyscale Images to 72ppi in order to keep the file size down. Keep the quality at Medium. If size doesn’t matter then bump up the resolution in order to keep the images nice and crisp.

Hit Export and, there you go! You’ve made an interactive, screen resolution, printable PDF. Clever

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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