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One of the hardest challengers for an ezine publisher is to keep your su

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

bscribers reading your emails. You are only really in business when you

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

subscribers are reading your emails. If you are selling a product your

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

self, if your subscribers are not reading your emails, they are not buyi

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

g your products. If you are selling advertising and solo ads, if your s

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

bscribers are not reading your emails, you are not selling a lot of adve

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

rtising because the advertisers don’t like the response they are getting

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

So how do you keep your readership high?

I think that one of the most

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

important things is credibility. Your subscribers have to consistently

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

receive value when they read your emails, or they will stop opening them

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

stop reading them, and stop clicking through to the links in them. You

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

must make sure that you never mail anything that does not give the subsc

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

riber value. Make sure that the subject line matches the content of the

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

emails – no trickery. If you trick your subscribers into opening an ema

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

l they would not like to if they knew what was really in it, you get uns

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ubscribes and people quit opening your emails.

Another thing to do is t

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

keep the readership involved. Ask them questions, then answer the ques

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ions mailbag style, so everyone can see that you are communicating with

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

your list. If you do this, some subscribers will actually look forward

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

o receiving your email, rather than deleting it as soon as it comes over

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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