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    A few years ago (it seems like yesterday) people were hardly waiting for that special message "you've got email". Now most of us open our login onto our em
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    ail accounts with fear, scared of what might pop-out of an email and infect our computers with God knows what virus or spyware. Spammers make it impossible
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    for many to trust even emails and e-newsletters from legit companies. Is that a surprise? Be honest: have you never seen a PayPal-alike newsletter - a ph
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    ishing attempt in disguise?

    Spam makes it really difficult for website owners and honest online entrepreneurs to promote their products and services using
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    mails. Nowadays building up a newsletter mailing list and even publishing a newsletter are matters of nerves and guts. This is not a job for the weak.

    In
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    2006 spammers have almost tripled the amount of email spam compared to 2005. They use different publishing techniques to fool even the most sophisticated
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    spam blockers. On the other hand, overzealous spam blockers stop the delivery of genuine emails.

    Considering the legal problems that might occur if you se
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    nd out bulk unsolicited emails (aka spam) the best choice for you is to try to build up a good opt-in base with email addresses from clients and visitors th
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    t really WANT to receive news from you. Make them confirm their subscriptions (you don't want a lawsuit, do you?). Once you have that you may start publis
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    hing.

    • Keep the design simple - a two column newsletter works best. Contrary to what you might believe, HTML is fine. Publishing a newsletter in HTML pr
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    ovides for more formatting options and allows you to insert valuable images - product pictures for example. Spammers use both text emails and HTML to sprea
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    d their messages around; so don't believe that if you send out a text newsletter you have more chances of success. On the contrary: a well designed HTML ne
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    sletter might really capture reader's attention and determine them to click on a link and visit your website or even to answer you with a product inquiry.

    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    • Keep the use of images to a minimum. Make sure these images have browser resolutions and that they load fast and are relevant for your news. • Avoid usi
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    ng images and additional graphics just because "they are cool".

    • To avoid being blocked by overzealous spam blockers, do not to use in your newsletters wo
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    rds like medicine, casino, big money, cialis, gambling, hair loss, home finance, levitra, paxil, poze, roulette, porn related words and so on. Don't use th
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    word "FREE" in capital letters. More problem words are listed on spamassassin.org

    • Write your message in a clear manner: plain English and short sentenc
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    es. Don't ramble on! The new spam blockers might block text that looks like "When she turned, he saw a sweat stain that looked vaguely tree-like rising up
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    her back. But Annie was the head maternity nurse, after all, so she was always going in and out". - this is a fragment from a spam email to give you an id
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    ea on how not to write your texts.

    Well, that's about all the basic tips you need to know to publish a newsletter that is not going to be mistaken for spam


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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