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The email newsletter (e-newsletter or ezine) is not only an excellent advertising promotion vehicle for your business in general; it can be a web promotion tool for your new services and any affiliates you represent. To create newsletters is an optimum way to stay in contact with your customers, let them know about new offers, and build good will, trust and credibility. You might want a church newsletter, a membership email

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

newsletter,a positive PR newsletter, etc.

There are few downsides when you create newsletters, except it requires a time investment. Internet marketing online (or web promotion) can seem intimidating and you may have looked into some Internet marketing consultants and found they were too expensive.

If you are on a limited budget as a start-up business, then I have great news for you. You can create newsletters practically

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ree. Yes—from obtaining well-written free articles and delivering your ezine to subscribers, to web promotion—it can all be done practically free.

Here is how to write a newsletter in eight easy steps:

If you don’t subscribe to newsletters in areas that interest you, now is the time to join them. To find them, go to ezine directories such as The Ezine Directory or The Directory of Ezines. Put on yo

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

r investigator hat and brew a pot of coffee or tea. Your mission is not just to read sample newsletters, but also to study them to get your newsletter design. Write down what you most like and least like about each. Make a rough outline of how favorite ezines arrange articles, ads, and links—in what order and format. From this research, you will get an idea of what you want to create. Newsletter design as well as n

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

wsletter format is often best when it is simple, not fancy. It is not plagiarism to do an ezine with a similar look and feel of an existing ezine. It’s called “don’t reinvent the wheel.” It would be plagiarism, of course, to copy their content or design exactly.

Now you’re ready to begin creating newsletters. Start with something as basic as a text editor program. You can create your own newsletter templa

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

e with it. Alternatively, you can obtain free ezine templates. Type in the words free ezine templates and/or free newsletter templates into your search engine to get locations. If you create your own newsletter template, place a grid at the top of your page to help you keep the line length at 65 characters. The reason for this is that when the ezine is sent by email, other people may not receive it as it looks

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

when you send it out. Their settings may not tolerate anything longer than 65 characters, so if you had a longer line, it would wrap it around and cut off part of your sentences. Alternatively, you can use a text program to stop at 65 characters for you. If you use Note Pad, you will have to keep your line length manually. If you use certain text editors like Text Pad, you can pre-set it to stop at 65 characters.

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

You have your newsletter design and an outline to go by. You should also develop a “theme” for your ezine. Choose a short, memorable newsletter name. What will the newsletter focus on? Keep your topic in mind as you develop each issue. Write down the type of people you think will be interested in your topic. That is your target audience. Keep them in mind as you create newsletters. You have several choices for your art

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

cles. Write them yourself. Pay a writer to write articles under their name. Pay a writer to “ghostwrite” the articles under your name. Get free articles. Use an exchange tactic: One free article for free classified advertising; or free newsletter for one article. Most ezine publishers use a mixture of all of those. To get free articles, consult sites such as Ezine Articles.com or Go Articles.com. Or put the words f

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ee article into a search engine to find more.

Now you have your articles. What ads are you going to place in your email newsletter? Well, what products or services do you want to promote? You can write your own ads or you can hire a copywriter. If you’re on a tight budget, read through the classified advertising in magazines, and in the ezines you subscribed to, and study the ads. Look in several issu

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

s of the same magazine. Notice if you see an ad repeated month after month. That ad must be pulling in orders. If an ad asks the customer to order, it is a direct or hard-sell ad. (This is rarely done in small classified-type ads since there is not enough wording to properly describe the product or service). If an ad invites the customer to call or email for more information, or to click on a link for more information, th

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

t’s a soft-sell ad or a “two step” ad. The ad is step one. The follow-up info is step two. In a two-step ad, the follow-up ad is the hard-sell that presents a fuller description and asks for the order. Write down ads that you think are really good. With these as references, develop your own short ads until you can afford to hire a professional copywriter.

Now you have content, articles and ads. You need a way t

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

send your email newsletter to subscribers. It is extremely helpful if you also have a website (that’s another article, but websites can be easily and inexpensively done too). If you have a very small list to send your ezine to, you can use your favorite email program. Are you ready for this? There are also places that you will send your ezine out free for you and manage your subscriber list. The exchange is they will wan

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

to put an ad for their company in your ezine. They are called list servers. Two good ones are E-Groups and Listbot. To find more, just input list servers into your search engine. Alternatively, purchase newsletter software or hire a professional service to do it for you.

Now, you have your free ezine set up and ready to go. You have secured your method of delivery. You know your target audience. You ha

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

e your articles and your ads. Issue one, your pride and joy, is finished. Who is it going to? You need subscribers. If you have an existing customer list, they should be converted to subscribers. To get people to subscribe, they need to know about your ezine. It’s time to announce your ezine to the world with web promotion tools. I’ll bet by now, you have already guessed you can get this done free too! (Don’t you love

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

the Internet?) You may start with newletter-library.com and list-promote.com. Find more with a search engine. Add your free ezine to the ezine directories you found in Step #1.

Compose a free article that you will give your subscribers as incentive to join. Now, you are getting subscribers and issue one really needs to hit the great-cyber-highway, doesn’t it? Make sure that you send a test copy to yourself first

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

to see how it will appear before your subscribers do!

Nothing like planting a seed and watching it grow! But you will need to help it along with web promotion and positive PR. Start with producing a quality ezine. As you go along, you will develop more expertise. The important thing was to begin –to plant the seed. You can achieve good PR and web promotion results in many ways. I can’t discuss them all in the s

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ace of this article, but I can give you some advertising promotion ideas to think about:

Advertise your ezine by placing classified ads in other email newsletters with large subscriber lists that appeal to your own target audience.

Fuel advertising promotion with ad exchanges with other ezine publishers (i.e. I’ll help your advertising promotion if you’ll help mine!)

Go all

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

out with web promotion by placing banner ads on complimentary web sites—you will need to create these or have someone do it for you.

Accomplish web promotion with link exchanges.

Is it really this simple? Experienced email newsletter publishers are shaking their heads “no!” There is a mountain of information still to be learned about ezine publishing, PR, and advertising promotion. But you

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

can climb that mountain as surely as anyone else has. The journey of a thousand miles begins with a single step. If you can walk through these eight steps, you will start a great journey. You can learn as you go and as you grow. The important thing to remember is that all the information you need is readily available to you if you’re willing to look for it. For, when the student is ready, the teacher always appears

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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If you are starting a small business with a limited budget that doesn't allow you to hire a graphic designer to design business cards for you, then there is no need to lose heart.

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