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There are lots of ezines (newsletters) out there that offer free classified ads to new subscribers (and many even offer free ads on an ongoing basis

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

).

This can be a nice little source of free traffic and exposure for your website/ebook/ezine but, if not handled properly it can have its downside

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

.

The biggest problem is that, by joining a whole plethora of ezines your mail box risks becoming very crowded very quickly, and it's easy to becom

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e overwhelmed with it all.

This is especially true if some of those ezines send out messages every single day -- as many do.

To get around this, a

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

d to keep your free ezine advertising campaign under control, follow these steps:

STEP 1. Create a separate e-mail address for your ezine subscript

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ions (e.g. my_ezines@.....).

STEP 2. In your email software (e.g. Outlook Express) create a folder (directory) called 'free_ezine_ads'.

STEP 3. Us

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ing your e-mail software set up a rule that sends all mails that arrive to your e-mail address 'my_ezines@....' to the folder called 'free_ezine_ads

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

.

STEP 4. Prepare the free ad you want to place in the ezines and keep a copy of it handy in a text file.

Different ezines have different rules ab

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

out the size of ad they will accept. Study each one carefully and be sure to comply with all their submission guidelines.

You may also want to cons

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ider the mood and tone of each ezine, and create different versions of your ad for each one.

STEP 5. Submit your ad to each ezine editor. Be sure t

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

double-check that you've complied fully with their submission guidelines.

STEP 6. For those ezines which give you a one-off ad, it's time to re-as

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

sess their value to you. If you don't find the content useful or interesting, you should unsubscribe rather than let it clog up your 'free_ezine_ads

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

' folder.

Remember, though, if the ad in that ezine drew a good response from its readers, you can always check out their advertising rates and see

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

if it's worth paying a few dollars to place your ad again (or, if you're sneaky, you could try re-subscribing at a later date and doing it again, m

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

king some changes to disguise your wicked deception:-)

STEP 7. For those ezines that allow free ads on a regular basis, make a list of all the subm

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ission deadlines and make it part of your regular marketing routine to check that list and see if you're due to place an ad.

Finally, as you contin

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ue placing regular ads with those ezines, be sure to continue measuring their effectiveness. In many cases you'll appear in the middle of 20 other a

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

s, so it may not bring in much of a response rate.

Likewise, the response rate from each ezine is likely to drop off over time -- especially if you

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

don't vary your ads.

Decide for yourself whether it's worth your while continuing and be sure to try out different ads to see which ones work best

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

with that readership.

And there you have it, a pretty straightforward approach to keeping on top of things when it comes to free ezine advertising

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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In restaurant point of sale a product passes through certain distinct stages during its life. This cycle of stages is called Product Life Cycle or PLC. The PLC is normally presented as a sales curve spanning the products course from introduction to exit. Concept lies in the fact that each stage in the restaurant point of sale is characterized by a typical market behavior and consequently each stage lends itself to the application of a certain specific marketing strategy. Understanding the PLC concept and managing it effectively can help prolong the profitable phases of the life span of a product.

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