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If you want to know how to get good links to your web site: there is no finer way than getting one-way links from human edited, high page rank dire

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ctories.

But would you be surprised to know, linking to some PR6 directories will gain you very little benefit?

The conventional wisdom o

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

f linking to directories -- particularly the high page ranked directories edited by a human -- is very sound, for this reason. Although search engi

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

nes -- particularly Google (thanks to their Latent Semantic Indexing) -- are getting better at deciding how good web site content is, they still re

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ly heavily on "votes" to your site in the form of links from authority sites. There are few better authority sites than the human edited directorie

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

s, because a human editor will vet a site before including it in their directory.

Therefore, if the Googlebot detects a link from such a direc

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

tory to your site, it takes notice. It then looks to see what page rank has been attributed to the page from whence comes your link.

And that'

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

s where the problem starts, because all apparently equal directories prove not to be equal in practice.

You see, there are plenty of lists of

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

directories around, and some even give you the page rank of each site. Being a shrewd webmaster, what are you going to do? Of course you are: you'r

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

e going to submit your web site to the directories with the greatest page rank. Obvious, isn't it?

Unfortunately, sometimes the obvious isn't

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

the best course of action.

Here's some figures for you, based on a target Google page rank of six. You've got a good site with plenty of good

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

content and you submit it to the directories. Here's the number and type of link you need to obtain to get that coveted page rank of six.

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

You either need about 500 links to your site with a page rank four.

or . . . 100 links to your site with a page rank five.

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

or . . . just 18 links from pages ranking six

. Which would you choose?

Unfortunately, although there are quite a few directo

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

ries with a page rank of six -- several as high as seven or more -- this often only applies to the home page. As you drill down to the page where y

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

our link is likely to be placed, you will often find the page rank going lower and lower. Sometimes, the page where your link would be coming from

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

will have a big fat zero. And this can even happen with many sites with home page rank of six or more.

You need over 90,000 links from pages w

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ith a page rank of at least one to make a dent in that PR6 rating for your web site links. So, if you aren't going to waste a truckload of time, yo

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

u must be very careful to evaluate directories using a page rank indicator tool. Don't bother inviting any directory to vet your site until you hav

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

e vetted them -- particularly the page your link will be on.

Copyright 2006 Paul Hooper-Kelly and www.InternetMarketingMagician.com

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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