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This is an eternal question. Search engine optimizers would remain glued to their computer screen to take in the first hint of any PageRank update as and when that occurs. And when it occurs, it will be an anxious wait till the dust settles, before scurrying off to

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

rework ways to claw back in ranking in case the new PR reduces.

Why so much bother? Does PageRank really matter? The short answer is yes, PageRank does matter, but not as much as it is made out to be. Let us talk things over.

What we know The fir

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

t lesson on PageRank will be an unquestionable reference to what Google says. According to Google [http://www.google.com/technology/], “PageRank relies on the uniquely democratic nature of the web by using its vast link structure as an indicator of an individual pag

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

e's value.”

Elaborating, Google says 2 things. One, more the number of incoming links to a webpage, more is the ‘number of votes’ for that page. But then comes the second rider. Google also analyzes the page that sends links and attempts to figure out how ‘importan

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

’ or ‘relevant’ this page (rather its content) is vis-?-vis the page which it links to.

Broadly speaking, links between 2 travel-related webpages make much sense in the eyes of Google than that between a travel-related webpage and another concerning, say a watch ma

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ufacturing company.

A succinct yet clear explanation of PageRank Technology is provided by Google here [http://www.google.com/corporate/tech.html]. The underlying idea is to provide surfers as accurate search results as possible. The ‘life of a Google query’ though

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

lasting barely a second, is a mind-boggling go-between through several stages before an answer is delivered.

What we do not know Howsoever revealing may Google’s explanations be, the bottom-line remains that for most of us, calculation of PR cont

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

nues to be an enigma. Does any one know for sure how PR works? Ian Rogers of IPR Computing has in this essay [http://www.iprcom.com/papers/pagerank/] explained fairly well as to how PageRank is calculated by Google.

However, even if the mathematical equation to cal

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ulate PR is known, what is not known is which set of its data Google uses from its databank for finding out the PageRank of your webpage. This essentially translates to no more than second-guessing as to what the next PR would be. It would therefore be not wrong to

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

say that most of the users (and indeed the so-called SEO experts) do not know what their PageRank would be next time. (Having said that, I must not consciously deny readers of this article to know what their supposedly Future PageRank [http://www.seochat.com/seo-too

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

s/future-pagerank/] will be.)

Why the hype And herein lies a superb marketing strategy. Ever wondered why Google thought it pertinent to let PageRank displayed in its toolbar? On the face of it, there is no need really, except to ‘stoke’ the fire

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

f chasing a mirage. You see a mirage as much as you know how PR is calculated. But try as best as you would, you cannot decide your PR.

In the process Google gains. An enormous volume of writings (like this one) centers around Google. Whatever Google does is news i

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

n an instant. There is a whole lot of ‘pure’ Google-watchers out there whose job it is to only report on the giant search company. Publicity sans cost, not bad that.

The link companies Google’s wish notwithstanding, there is no denying that PageRa

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

k mystery has given birth to thousands of link-related business. Since Google is explicit in explaining at how it looks at links, it has been easy for link-making companies to work out their preliminary business strategy. Beyond that it’s purely rat race of garnerin

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

share of link-hungry websites. All the time, Google remains unfazed, except occasionally churning it topsy-turvy to keep PR mystery alive.

What would you do You need not overly bother about PageRank. Do not get me wrong! PageRank is very real. Wh

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

at is not is your ability to alter it any sooner. There should not be any express-effort to ‘acquire’ links. Instead, maintain focus on adding and enriching your web content, for that and that only would create a permanence of interest among your viewers over a peri

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

d of time.

Emphasis must be on creating value to your viewers’ time, so that there is always something new to learn, something more to know. Along the way if you pick up a good link or two every now and then, that will be more than welcome.

What, if you ar

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

in hurry Not everyone is destined to wait for a hike in PageRank. Then again, even a high PR may not instantly lead to bigger traffic. So pretty soon, you may ponder how long it will be to profit from your web venture. Profit may be to earn publicity (blo

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

gs for example), to make your readers giving consent to your paid newsletter, to sell your products or services (or even selling others’ products or services), or suchlike.

If indeed you want to cut short your long wait so as to profit from your web venture, Google

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

has a ready solution. It is about targeted keyword advertising program, called Google AdWords. In sharp contrast with PageRank, Google lets AdWords users to actually control their accounts in order to attain more visibility. But that is another story for another day

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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