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    The idea of blogs is not new. Basically it is an open internet diary or comment book that allows anyone
    According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
    to have their rant, be heard on important issues, update people on events or services or just record th
    ; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

    Examples of combination products may in
    tedious details of their day. People were doing this quite happily for many years, until, like many th
    lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

    ings on the internet, it became a buzz-word. Pretty soon everyone needed a blog, and those of us who ha
    here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
    been blogging for years had to rename our rants and records to blogs so people knew what they were.

    Th
    d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

    Combination pro
    n someone figured with all these people wanting to be heard there must be some money to be made, and com
    ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
    panies used blogs as ways of drawing customers back to their sites and selling them over and over. And
    easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
    round about that point things started to get spammy.

    Software popped up to automatically create blogs,
    nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
    o update blogs, to draw content from one blog to another site and just about everything else to do with
    and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
    blogs. One of the popular drawcards of blogs is the dialogue created as people respond to the bloggers
    ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
    omments, but spammers quickly realized that this was a way to get their links on highly rated pages, and
    ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

    Following aspects would a
    blogs became another form of spamdexing.

    Spamdexing is the use of artificial methods to inflate the sea
    dd to the challenges in developing combination products:

    Which markets to tap where the combination products can do fairly well?
    Which combination prod
    rch engine rankings of a website. One of the current trends in the spamdexing world is cross linking in
    cts are meaningful and rational?
    Which therapeutic categories to select?
    Which Combinations can address unmet needs of the patients?
    Do combin
    it's various forms. By allowing comments on a blog site, the blogger was also offering free advertising
    tions increase the patient compliance?
    What would be the developing cost?
    How to tackle the risks encountered during combination product developmen
    space to spammers. Not surprisingly the spammers jumped at this opportunity and the bloggers found thei
    t?

    As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
    r comments bombarded with automatically posted, irrelevant spam replies.

    Luckily spam in this form is m
    ping new procedures for reviewing their safety, efficacy and quality.

    Professional from academic institutions, pharmaceutical industries, health care indust
    ch easier to combat than email spam. Bloggers required accounts for comments, or added a simple securit
    y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
    question that must be answered to participate, or a variety of other simple additions that were difficu
    .

    As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
    lt to automate, or easy to detect automated attempts. The cost was the ease and user friendliness of bl
    elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

    Companies that provide selfless information through particip
    gs, and people must now accept the slight inconvenience as the price to be paid to allow free discussion


    tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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