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It's hard to be impressed anymore. But when I learned of the phenomenal achievements of Tim Berners-Lee, I became not only impressed, but awestruck.

Tim Berners-Lee is credited with inventing th

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

e World Wide Web. And what did you do today?

The World Wide Web is the portion of the internet which is basically involved with websites, as opposed to other internet usages such as email or FTP

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

Fifteen years ago, there was no web and only a very rudimentary internet. No Travelocity. No iTunes. No Ebay, Amazon or American Singles. No Mapquest. No Google, Yahoo or AOL.

But then came Ti

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

Berners-Lee.

In 1989, at the European Particle Physics Laboratory where he worked, he proposed that "a global hypertext space be created in which any network-accessible information could be ref

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

red to by a single "Universal Document Identifier"."

A year later, he developed the of the language of the web, HTML (Hypertext Markup Language), along with the rules by which information flows

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

cross the internet, HTTP (Hypertext Transfer Protocol), and the web addressing method, URL (Uniform Resource Locator).

In order to demonstrate this new technology, he was also involved with the

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

evelopment of two other essential firsts: a web server - the computer which hosts web content, and a browser, the software which enables users to access web content.

In a classic example of tech

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ology enabling its own replication, some of the first content posted on the first web server was the specifications for HTML, HTTP, and URL. This allowed academics, and later business people acro

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

s the world to set up their own web servers and connect to the web.

Soon, in 1994, he organized the World Wide Web Consortium at MIT, and also in France and Japan to promote ongoing development

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

nd uniform implementation of new protocols. Reality check: that was only 11 years ago!

Now a few quotes from Mr. Berners-Lee to demonstrate the largeness of his thinking:

"The dream behind the

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

eb is of a common information space in which we communicate by sharing information. Its universality is essential: the fact that a hypertext link can point to anything, be it personal, local or g

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

lobal, be it draft or highly polished."

There is a "great need for information about information, to help us categorize, sort, pay for, own information..."

"There was a second part of the dream

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

too, dependent on the Web being so generally used that it became a realistic mirror (or in fact the primary embodiment) of the ways in which we work and play and socialize. That was that once th

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

state of our interactions was on line, we could then use computers to help us analyse it, make sense of what we are doing, where we individually fit in, and how we can better work together."

Th

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

se words point to a vision of a global interconnectedness which could actually help us understand ourselves better, at many different levels, and assist us in realizing our optimum placement with

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

n the global community.

Berners-Lee does not stop at that utopian vision, he goes on to map out where we need to go next:

"...very few people in practice have access to intuitive hypertext crea

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ion tools."

A next step, therefore, would be to develop and disseminate the tools to create web content, so that the mass of web visitors become not just surfers, viewers, searchers and download

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

rs. They become creators, too.

Now, in 2005, it is estimated that over 700 million people, or over 10% of the world population have internet access. From 1994 until present the web has grown an

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

verage of 275% each year. All of this and much, much more has stampeded into and created our future as a direct result of the work of Tim Berners-Lee.

As I said, I am awestruck.

Quotes from Mr.

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

Berners-Lee were taken from his website, which I highly recommend: http://www.w3.org/People/Berners-Lee/Overview.html

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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