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Most people believe the money ghosts that infest the City of London are not

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

hing more than a myth. They are wrong. These ghosts do exist and they steal

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

millions of pounds every year.

Susan Flint from Bad Moon Investments says

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

, 'The ghosts steal from accounts, from share deals, and they even steal th

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

loose change in bankers' pockets. It is a serious problem.' I believe it i

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

s a problem without a solution. From my research I have found out that thes

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e money ghosts are the ghosts of bank clerks and accounts clerks who in the

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

r lifetime were jealous of the far more successful bankers and traders whom

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

they came into contact with. Not even exorcisms will help. The ghosts are

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

so incredibly stubborn that there is absolutely no way they will leave the

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ity of London until they get what they feel they deserve. And even if veter

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

an ghosts finally do move on, I imagine younger and more aggressive ghosts

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

will take their place.

Well, can anything be done about this? I'm not sure

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

this is a solution, but maybe banks and financial businesses in the City c

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

n set up a special fund that will curb the worst excesses of the money ghos

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ts. The ghosts will be allowed to draw money from the fund when it suits th

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

em. This idea was suggested to me by Arthur Simmons from the Chaos College

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

f Finance. I suspect though it won't really have much of an impact. The fac

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

t is these money ghosts enjoy stealing, and they probably won't want to be

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

seen as charity cases. I feel sorry for them in a way. It's a sad situation

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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