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One way of trading that is often overlooked by many traders, is trading price and time. This meth

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

od of trading forecasts potential turning points in the markets. Two types of trading methods rel

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ated to price and time are Fibonacci and the Gann Square of Nine.

Both these methods will allow

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

you to find potential reversal points by both the price of the market and the date.

For Fibonacc

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

i, we take the previous high and low that stands out, as well as their respective dates. We then

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

calculate the potential turning points by using Fibonacci ratios like .382, .50 and .618. Let’s s

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

uppose we are looking at a market that had a low of 300 and a high of 400. The low was made on Ja

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

nuary 1st and the high was made on June 30th. We take the difference in the prices and the dates

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

and multiply them by the ratios mentioned.

For the price, we subtract 400 – 300 = 100. We then m

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ultiply 100 by the ratios and subtract them from the second number which is 400.

So 100 * .50 =

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

50. 400 – 50 = 350. The .50 ratio gives us a reversal point of 350. Do the same for the .382 and

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

.618 ratios.

100 * .382 = 38.20. 400 – 38.20 = 361.80.
100 * .618 = 61.80. 400- 61.80 = 338

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

.20.

We now have 3 potential turning points in the market:

Price1: 361.80
Price2: 350.00

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

r> Price3: 338.20

For the time, we have applied the same calculations of the difference of the

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

2 dates and we get 3 dates where we have a potential reversal:

Date1: 9/6/2006
Date2: 9/28/

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

2006
Date3: 10/19/2006

We are watching to see if Price and Time “Meet”. When the potential

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

price hits at one of the potential dates, this means that Price and Time have met.

Gann is not a

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

s easy to do by hand. You will need a program or the Gann square of nine in printed format to be

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

able to see what the forecasted price reversals are. Also for Gann , only one price and date are

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

entered. It is based on the squares in the pyramid and their mathematical alignment to each other

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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