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People are up to their eyeballs in debt. With interest rates rising, many people are experiencing severe difficulties keeping up with thei

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

r credit card and home loan obligations. The problem has been fueled, in large part, by the extremely low adjustable rate mortgages which

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

many people took advantage of during the past few years to purchase homes that they could really only afford at those rate levels. Unfortu

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

nately, those rates have now increased, which means that the monthly payment obligations have increased substantially.

The result of these

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

events has been devestating for many, and you should not feel isolated or alone if this is your situation. The problem is rampant, and ma

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ny people are in the same boat looking for ways to weather the storm. Specifically, people are living in houses that they can't really aff

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ord. On top of that, the housing market has cooled which means that they can't sell the houses at prices that would allow them to pay off

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

the adjustable rate mortgages. Accordingly, desparate to keep up with their adjustable mortgages as much as possible, people are forced t

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

o use other forms of credit to pay for their daily needs, namely credit cards with astronomical interest rates. At the end of the day, mos

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

t or all available cash goes to the adjustable rate mortgage, which leaves amounts still owed on the mortgage plus additional amounts owed

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

to the credit card companies at much higher rates.

While there are no great options, the best may be for people to attempt to consolidate

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

their debts into one, with the lowest interest rate possible. This maybe a home equity loan, which will typically carry a much lower inter

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

est rate than those charged by the credit card companies. Other advantages of home equity loans are that they reduce the number of lenders

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

to whom payments are owed, and the interest paid on the loans will be deductible for tax purposes.

If the home equity loan is not availab

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

le because there is no equity left in the home, people should look for other single sources of loans with the lowest available interest rat

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

es. This will consolidate all debt with one lender at one rate (the lowest available), simplifying the situation for the borrower.

Finall

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

y, of course, in the process of consolidating debts with a home equity loan or other form of debt, all efforts should be made to negotiate

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

with your existing lenders to eliminate the debts owed by paying some discounted amount. If, take for example, you owe $100,000, see if yo

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

u the lender will accept something less, like $50,000, to resolve the debt completely. While no lender wants to do that, they are often wi

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

lling to negotiate such arrangements simply for the sake of being done with the loan and not incurring any greater losses.

Hope this helps

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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